Nongenomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation

Nongenomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation.

Glucocorticoids (GCs) are used to treat pregnant women at risk for preterm delivery; however, prenatal exposure to GCs may trigger adverse neurological side effects due to reduced neural progenitor cell (NPC) proliferation. Whereas many established cell-cycle regulators impact NPC proliferation, other signaling molecules, such as the gap junction protein connexin-43 (Cx43), also influence proli...

Communication in Airway Cells TLR2 Regulates Gap Junction Intercellular

ATP Released via Gap Junction Hemichannels from the Pigment Epithelium Regulates Neural Retinal Progenitor Proliferation

The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate DNA synthesis in neural retinal progenitor cells. Here, we show that the RPE r...

Assembly of gap junction intercellular communication channels.

788 with a lipidlprotein molar ratio of 100:1, a value close to that found in most biological membranes [21]. The data show that the calculation of distances between sites within the monomer of a membrane protein of a cross-sectional diameter of 5 nm based only from FET efficiency measurements is largely speculative in most cases in native biological membranes. Because the contribution of FET t...

FGF-4 regulates neural progenitor cell proliferation and neuronal differentiation.

The FGF-4 (fibroblast growth factor 4, known as HST-1) protein is an important mitogen for a variety of cell types. However, only limited information is available concerning tissue distribution and the biological role of FGF-4 in the brain. In situ hybridization analysis revealed localization of mouse Fgf-4 mRNA in the normal postnatal mouse hippocampus, subventricular zone (SVZ), and the rostr...